- Harder To Kill
- Posts
- You Were Misled About Cholesterol—and Statins Are Just the Start.
You Were Misled About Cholesterol—and Statins Are Just the Start.
#131

Time Magazine January 13, 1961
Before You Fill That Prescription...
“All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident.”
For decades, men like you have been told the same story: high cholesterol causes heart disease, and statins are your best defense—especially if your father had a heart attack, or you were led to believe lowering cholesterol might protect you from dementia like your mother’s.
But what if that story was wrong?
Or at least, dangerously incomplete?
It all started with a man named Ancel Keys, whose appearance on the cover of Time magazine in 1961 helped launch the war on fat and cholesterol. His influence still shapes what your doctor believes today.
We’ll come back to that at the end of this guide.
In the Argent Alpha community, we don’t outsource our thinking—or our health.
We question dogma. We follow the evidence. And we take ownership of our future.
This guide dismantles one of the most persistent medical narratives of the last 50 years. It’s based on peer-reviewed studies, expert opinion, and the lived experiences of men who refused to settle for the standard prescription.
You’ll hear from cardiologists like Dr. Stephen Sinatra, longevity experts like Dr. Peter Attia, neuroscientists like Dr. Dale Bredesen, and functional medicine leaders like Dr. Mark Hyman.
You’ll see the data most doctors won’t show you.
And you’ll come away with a clear plan to protect your heart and brain—without compromising your strength, libido, or mental clarity.
Because in this community, we don’t aim for average.
We aim for optimal.
And the truth, once ridiculed, is finally becoming self-evident.
A heads-up before we dive in…
At the end of this piece, you’ll find a brief but important sidebar on Ancel Keys, the man whose flawed research shaped the last 50 years of cholesterol dogma. You’ll want to see how it all started.
And next week in issue #132, we’ll introduce you to The Rebel Alliance—28 world-class experts who broke from the script and built a better model for heart and brain health. Don’t miss it.
The Myths That Need Breaking
You’ve been told your cholesterol is too high. You’re handed a prescription. You’re warned about your family history. The subtext? You’re broken, and a pill will fix you.
But what if the very foundation of that narrative is flawed?
Here are the four biggest myths driving the overprescription of statins—and why men like you should start asking better questions.
Myth #1: High LDL Cholesterol Is the Primary Cause of Heart Disease
For decades, LDL—the so-called “bad cholesterol”—has been painted as the villain. But for metabolically healthy men—those with body fat under 20%, strong insulin sensitivity, low inflammation, and good cardiovascular fitness—LDL alone is a poor predictor of heart disease.
A 2015 BMJ Open meta-analysis of 68,094 adults over 60 found that higher LDL was linked to lower all-cause mortality, particularly in those without metabolic disease.
Dr. Malcolm Kendrick (The Great Cholesterol Con) and Dr. Uffe Ravnskov (The Cholesterol Myths) argue that cholesterol is often a repair molecule, not a perpetrator. It shows up to patch damage—not cause it. The real enemies? Inflammation, insulin resistance, and oxidative stress.
But here’s the catch: If you’re carrying more than 20% body fat, you’re unlikely to be metabolically healthy.
Excess fat—especially visceral fat—is inflammatory, hormonally disruptive, and a driver of poor metabolic outcomes. In that context, LDL becomes part of a dangerous metabolic environment, especially when it shows up as small, dense particles.
If you’re lean, strong, and training like an athlete, you deserve a different lens than the one used for sick, sedentary patients.
Myth #2: Statins Are a Safe, One-Size-Fits-All Solution
Statins lower cholesterol—but they don’t address root causes like inflammation, oxidative stress, or metabolic dysfunction. And they come with real costs: muscle pain, hormonal disruption, memory loss, and a 9–12% increased risk of diabetes (Expert Review of Clinical Pharmacology, 2015).
Even the benefit on lifespan is negligible. A 2021 JAMA Internal Medicine study showed that for primary prevention (no history of heart disease), statins extended life by just 3 to 4 days over five years—and that’s after taking the pill daily, enduring side effects like brain fog, muscle pain, and hormonal disruption, just to buy a long weekend.
Dr. John Abramson, author of Overdosed America, states it plainly: “Statins have been wildly oversold.”
Myth #3: Family History Determines Your Fate
Your father’s heart attack doesn’t seal your fate—your habits do. Genetics load the gun, but lifestyle pulls the trigger, as Dr. Peter Attia often says. If you’re lifting heavy, eating clean, keeping body fat low, and managing stress, you are not the same man your father was.
A 2018 study in Circulation found that even with high genetic risk, adopting a healthy lifestyle cut heart attack risk by 46%.
Myth #4: Lowering Cholesterol Is Always Good for Brain Health
Cholesterol is vital for brain function—supporting neuron integrity, myelin formation, and hormone synthesis. Aggressively lowering it with statins can backfire.
A 2014 study in Neuropsychology found that older adults with higher or stable cholesterol levels in late life performed better on certain cognitive tests, such as verbal memory and executive function, compared to those with lower or declining levels.
Research, including studies published around 2014 in journals like Neurology, suggests that older adults with higher cholesterol levels in late life may perform better on cognitive tests than those with lower levels, particularly when cholesterol remains stable over time.
Experts like Dr. David Perlmutter (Grain Brain), Dr. Dale Bredesen (The End of Alzheimer’s), and Dr. Georgia Ede warn that low cholesterol may increase the risk of cognitive decline, dementia, and Alzheimer’s.
Bottom line? These myths are being challenged by world-class physicians, cutting-edge research, and men who’ve lived through the consequences.
And if you’re living the Argent Alpha lifestyle—training, eating clean, sleeping hard, and maintaining 15% body fat—these myths don’t apply to you.
But if you’re not there yet?
Then yes, the risks are real—but not because of cholesterol.
Because of your internal state—inflammation, visceral fat, and insulin resistance.
The good news: those aren’t fixed traits.
They’re outcomes of your operating system.
And they can be changed—starting today.
What the Research (and Experts) Actually Say
For decades, men were told to fear cholesterol and trust statins. But a growing number of physicians, cardiologists, neuroscientists, and metabolic researchers are saying: We got it wrong.
These aren’t fringe voices. They’re top-tier experts from fields like cardiology, endocrinology, nutrition, and brain health—many of whom once followed the standard playbook and now reject it.
Here’s what they believe—and the science that backs them.
1. Cholesterol Isn’t the Villain. Inflammation and Metabolic Dysfunction Are.
Your body makes 80–85% of its cholesterol because it’s essential: for cell membranes, testosterone, vitamin D, brain function, and repair processes. The small amount you consume from food? Your liver adjusts accordingly.
“Cholesterol is a firefighter, not the arsonist.” —Dr. Stephen Hussey, chiropractor and heart attack survivor who attributes his event not to cholesterol, but to chronic inflammation and poor stress management.
Dr. Robert Lustig, pediatric endocrinologist and author of Fat Chance, points to sugar and insulin resistance—not fat—as the real creators of dangerous, small, dense LDL particles that increase risk.
Dr. Malcolm Kendrick, Dr. Dwight Lundell, and Dr. Uffe Ravnskov all reinforce the same idea: Cholesterol is part of the healing process. The real issue is what caused the damage in the first place.
Supporting Research:
BMJ Open (2015): Higher LDL linked to lower mortality in elderly adults
A meta-analysis of 68,094 adults over 60 found that higher LDL-C was associated with lower all-cause mortality in most populations studied.The Lancet (2017): Inflammation markers like hs-CRP predict heart events—even when LDL is low
The CANTOS trial showed that lowering inflammation—measured by high-sensitivity CRP—reduced cardiovascular events, even when LDL was already low.American Journal of Clinical Nutrition (2013): Dietary cholesterol has minimal effect on blood levels due to liver regulation
Research confirms that dietary cholesterol has little impact on blood cholesterol in most people due to the body’s tight regulatory mechanisms.
2. Statins May Do More Harm Than Good—Especially for Healthy Men
Statins reduce LDL, but they also:
Deplete CoQ10, damaging mitochondrial function and reducing testosterone.
Increase risk of type 2 diabetes (up to 12%).
Cause muscle pain, memory loss, and cognitive fog in many men.
Show marginal, if any, benefit for men without existing cardiovascular disease.
Dr. Stephen Sinatra, board-certified cardiologist: “We’re using a sledgehammer when what we need is a root-cause approach—nutrition, exercise, targeted supplements, and stress reduction.”
Dr. Duane Graveline, a former NASA astronaut and physician, developed transient global amnesia on statins—and became a whistleblower on their neurological side effects.
Dr. John Abramson of Harvard Medical School has testified to Congress on pharma’s data manipulation around statin trials.
Supporting Research:
JAMA Internal Medicine (2021): A study titled "Evaluation of Time to Benefit of Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years" found that for primary prevention, statins may take approximately 2.5 years to prevent one major cardiovascular event among 100 treated individuals.
Expert Review of Clinical Pharmacology (2015): The article "Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms" discusses potential adverse effects of statins, including an increased risk of diabetes, lowered testosterone levels, and elevated liver enzymes.
Journal of Sexual Medicine (2010): A study titled "Effect of statins on erectile function and sexual health" explored the association between statin use and sexual dysfunction, including erectile dysfunction and reduced libido.
3. Family History Isn’t Destiny—Lifestyle Is the Deciding Factor
Yes, genetics matter. But they’re only part of the equation. What you do every day—how you eat, move, sleep, and train—either turns those genes on or off.
This is called epigenetics: the science of how lifestyle influences gene expression.
A family history of heart disease or high cholesterol might load the gun.
But your habits pull the trigger—or don’t.
Studies show that even with high genetic risk, men who follow consistent movement, nutrition, and recovery routines dramatically reduce their risk of heart disease. In fact, a 2018 study in Circulation found that a healthy lifestyle cut risk by 46%, even in men with high genetic predisposition.
The bottom line: your daily choices hold more power than your DNA.
Dr. Peter Attia often reminds his patients: “Genetics load the gun. Lifestyle pulls the trigger.”
Dr. Gabrielle Lyon, founder of Muscle-Centric Medicine, promotes resistance training as a primary tool to fight metabolic decline and override genetic predispositions.
Dr. Mark Hyman emphasizes that functional biomarkers (like triglycerides, glucose, CRP) tell a more accurate story than your family tree.
Supporting Research:
1. Metabolic health, obesity, and risk of dementia – Alzheimer’s Research & Therapy (2023)
📌 Summary: This large population study analyzed different metabolic-obesity phenotypes and found that poor metabolic health—regardless of body weight—was associated with a significantly higher risk of dementia. Importantly, being metabolically unhealthy posed a greater risk than obesity alone.
✅ Key Insight: Metabolic dysfunction (e.g., insulin resistance, inflammation) is a stronger predictor of dementia than genetics or body size alone.
2. Poor metabolic health linked to worse brain health – University of Oxford News (2024)
📌 Summary: Using brain scans and cognitive testing, Oxford researchers showed that individuals with poor metabolic profiles had reduced brain volume, worse white matter integrity, and more cognitive difficulties—even if they were otherwise considered healthy.
✅ Key Insight: Markers like high blood sugar, triglycerides, and blood pressure correlate with structural brain changes tied to cognitive decline.
4. Cholesterol Is Crucial for Brain Function—And Lowering It Too Much Can Backfire
Your brain is made of fat and cholesterol—nearly 25% of your body’s total cholesterol is in your brain.
Why? Because cholesterol plays a critical role in:
Building and maintaining the myelin sheath that insulates your neurons and speeds up signal transmission
Forming synapses, the connection points between neurons where memory and learning happen
Producing neurosteroids and hormones, including testosterone and pregnenolone, which affect mood, libido, and mental clarity
When you aggressively lower cholesterol—especially with statins that cross the blood-brain barrier—you may disrupt these processes.
Low cholesterol has been linked to memory loss, brain fog, depression, and even increased dementia risk. A 2014 Neurology study found that older adults with higher cholesterol performed better on cognitive tests than those with low levels.
Statins can interfere with brain function in other ways too:
They deplete CoQ10, a vital nutrient for mitochondrial energy production in neurons
They may reduce testosterone, impacting mood and cognition
They can impair synaptic plasticity, your brain’s ability to adapt and rewire itself
And while some statins are hydrophilic (water-soluble) and may not cross into the brain, others—like simvastatin and lovastatin—are lipophilic and can enter brain tissue directly.
In short: cholesterol isn’t the problem—your brain depends on it.
Dr. Georgia Ede, psychiatrist: “Low cholesterol is strongly associated with increased risk of suicide, aggression, and cognitive decline.”
Dr. Dale Bredesen, author of The End of Alzheimer’s, includes optimal cholesterol levels as part of his cognitive reversal protocol.
Dr. David Perlmutter (Grain Brain) warns that low-fat, statin-supported strategies have likely made neurodegeneration worse, not better.
Supporting Research:
Neurology (2014): Older adults with higher cholesterol had better cognitive performance.
Dr. Ede’s analysis: Shows high LDL combined with good metabolic health is associated with reduced Alzheimer’s risk.
5. Metabolic Health Is the Strongest Predictor of Heart Disease—Not LDL Alone
You’ve been told to focus on total cholesterol or LDL.
But these are outdated, one-size-fits-all metrics that miss the real drivers of heart disease:
Inflammation
Insulin resistance
Arterial plaque
What matters more than a single number is the metabolic context behind it.
Lean, strong, inflammation-free men don’t get heart disease like overweight, inflamed men do—even with “high” LDL.
That’s why we don’t chase old metrics.
We track what actually predicts risk, builds resilience, and keeps you harder to kill.
→ See the next section: What You Should Really Measure
Dr. Ben Bikman, PhD in bioenergetics: “It’s not cholesterol that causes heart disease—it’s insulin resistance.”
Dr. Nadir Ali, interventional cardiologist: “You can have high LDL and still be low-risk—if the rest of your metabolic panel is strong.”
Dr. Paul Saladino and Dr. Cate Shanahan both emphasize nutrient-dense, low-carb diets to improve these real risk factors.
Supporting Research:
Circulation (2011): Triglyceride-to-HDL ratio is a strong predictor of cardiovascular risk.
Diabetes Care: Insulin resistance correlates with small, dense LDL—the most dangerous subtype.
Summary:
Cholesterol is part of a larger, more nuanced picture. And the real answers aren’t found in blanket statin prescriptions—but in lifestyle optimization, metabolic health, and understanding your actual risk profile.
What You Should Really Measure
If your doctor is still focused on total cholesterol, he’s playing checkers—when your life requires chess.
Why this matters:
LDL on its own is a blunt instrument.
It doesn’t tell you what kind of LDL you have (large and harmless vs. small and dangerous), or whether those particles exist in an inflamed, insulin-resistant environment.
Bottom line:
For men focused on performance, prevention, and long-term vitality, the question isn’t:
“Is your LDL high?”
It’s:
“Are you inflamed?”
“Are you insulin resistant?”
“Are you building up plaque?”
Because those are the real threats—not cholesterol in isolation.
Key Markers That Actually Matter
These are the markers high-performing men over 50 should care about. Not because they’re flashy—but because they actually predict risk, track metabolic health, and shape your longevity strategy.
1. Triglyceride-to-HDL Ratio
📍Goal: ≤ 1.5 is strong. Elite: < 1.0
Predicts insulin sensitivity and cardiovascular risk better than LDL or total cholesterol.
High triglycerides = excess carbs, poor fat metabolism, insulin resistance.
Low HDL = poor lipid transport and chronic inflammation.
A high ratio = plaque-building state.
Low ratio = metabolically resilient, low-inflammatory, long-game health.
🚨 Dr. Ben Bikman calls this the single best early indicator of insulin resistance.
2. hs-CRP (High-Sensitivity C-Reactive Protein)
📍Goal: < 1.0 mg/L
Measures systemic inflammation—a root driver of heart disease, cognitive decline, and aging.
Chronic inflammation fuels arterial damage—even if LDL is “normal.”
2017 Lancet study: hs-CRP predicts cardiac events independently of LDL levels.
Useful for tracking lifestyle interventions (diet, stress, sleep).
3. Fasting Insulin + HOMA-IR
📍Goals:
Fasting Insulin: < 5 uIU/mL
HOMA-IR (insulin x glucose ÷ 405): < 1.5
Most men focus on blood glucose. But insulin often spikes years before glucose ever moves.
Elevated fasting insulin = early metabolic dysfunction, weight gain, poor fat burning, and inflammation.
HOMA-IR exposes hidden insulin resistance—even in lean individuals.
Flag these early, and you buy yourself decades of resilience.
4. CAC Score (Coronary Artery Calcium Scan)
📍Goal: 0 = very low heart attack risk
CT scan that detects calcified plaque in coronary arteries.
A CAC score of 0—even with high LDL—means your heart is likely in great shape.
Widely available (~$100), no prescription required in most states.
Endorsed by Dr. Peter Attia, Dr. Nadir Ali, and many longevity-focused cardiologists.
Repeat every 3–5 years if stable.
5. Cleerly Scan (Advanced Coronary Imaging)
📍Cost: $500–$1,500
AI-enhanced coronary CT angiogram that detects soft, non-calcified plaque—the kind most likely to rupture.
Think of it as the CAC scan’s smarter cousin—next-level detail, especially for men with risk factors.
Helps guide treatment strategy, not just predict risk.
Ideal for men who want clarity and certainty about what’s happening inside their arteries.
6. ApoB, Lp(a), and LDL Particle Size
📍Targets:
ApoB: Lower is better; < 90 mg/dL ideal for low-risk men.
Lp(a): Test once—can’t be modified by lifestyle.
LDL Particle Size: Bigger = better (large, fluffy = low risk).
ApoB reflects the actual number of atherogenic particles—more predictive than LDL or total cholesterol.
Lp(a) is genetically inherited and increases clot risk. Most men don’t know they carry the mutation.
LDL particle testing (NMR or advanced lipid panels) reveals if your LDL is the dangerous, small/dense kind.
🚨 Dr. Peter Attia calls ApoB the #1 cholesterol-related marker to track.
7. NT-proBNP, Galectin-3, and ST2
📍No “perfect” targets—track trends with expert support
NT-proBNP: Indicates heart strain and early signs of heart failure.
Galectin-3: Marker of cardiac fibrosis and inflammation.
ST2: Emerging biomarker for cardiac remodeling and stress.
These are advanced cardiac markers, used in elite cardiology settings (Cleveland Clinic, Attia Health).
May not be necessary for everyone—but essential if your risk or symptoms rise.
8. Genetic Risk Panels (Optional, but Smart for Some)
📍Use for: strong family history, high Lp(a), or unusual statin response
Tests for genetic variants linked to Lp(a), LDL receptor function, ApoE status, and more.
Can explain why some men respond poorly to statins—or have elevated cholesterol despite clean lifestyle.
Options: upload your 23andMe or Ancestry data to Gene Food, SelfDecode, or consult a functional genomics provider.
One-time test with lifetime value.
9. Body Composition (InBody Scan or DEXA)
📍Goal: ≤ 15% body fat for disease resistance and peak performance
BMI is useless. What matters is your body fat percentage, visceral fat, and lean muscle mass.
High body fat (especially >20%) is strongly linked to insulin resistance, inflammation, testosterone decline, and cognitive decline.
Muscle is your metabolic engine. The more you preserve and build, the longer and stronger you live.
Tools like InBody and DEXA scans give a detailed view of where you are—and where you’re going.
📌 At Argent Alpha, we target 15% body fat or lower—not for vanity, but because lean and strong men don’t face the same disease risks as their overweight peers.
How to Get These Tests: Your Action Plan
Most primary care physicians won’t run these labs—because the insurance model doesn’t reward proactive health. That’s not their fault. But it is your responsibility.
Step 1: Decide Your Path
Ask yourself:
Do I want to run the tests now and review the results on my own?
Or would I rather partner with a doctor who shares my philosophy and guides the process?
Both are valid. Just don’t default to inaction.
Option A: Order Your Own Labs/Tests (DIY Path)
Most of these don’t require a doctor’s order. You can order them yourself and take control of your own data.
Function Health
Backed by Dr. Mark Hyman; 100+ labs including fasting insulin, hs-CRP, triglycerides, HDL, ApoB, Lp(a), and more
www.functionhealth.com
Ulta Lab Tests
Wide selection of individual lab tests and panels; includes fasting insulin, ApoB, Lp(a), advanced lipid panels, and more
www.ultalabtests.com
Life Extension
Longevity-focused lab testing and supplements; offers hs-CRP, ApoB, Lp(a), NT-proBNP, LDL particle size, and more
www.lifeextension.com/lab-testing
Private MD Labs
Discreet and fast lab test ordering for most metabolic and cardiac markers
www.privatemdlabs.com
InBody scan
Look for an Inbody model 570 or 580 to make sure you get a visceral fat measurement in addition to body fat % and skeletal muscle mass. You can find a location near you here.
Imaging for CAC and Cleerly Scans
These tests aren’t available through typical lab panels but can be scheduled through local imaging centers or advanced cardiology clinics:
CAC Score (Coronary Artery Calcium Scan): Often available for ~$75–$150 at hospitals, heart centers or imaging centers; no referral required in many states
Cleerly Scan (AI-enhanced CT angiogram): Offered at select cardiology clinics and executive health centers; check cleerlyhealth.com for providers
➡️ Pro Tip: Many private imaging centers now offer self-pay CAC scans without a physician’s order. Call ahead and ask for "self-referred cardiac CT with calcium scoring.
If you choose Option A, it’s a good idea to then find an aligned physician to help you gain deeper insights into your results and create an action plan to address any issues.
Option B: Work With the Right Physician
Prefer guidance and interpretation from the start? Look for physicians who optimize performance—not just treat disease:
www.ifm.org – Institute for Functional Medicine Directory
www.revero.com – Metabolic & lifestyle health practitioners
www.americasfrontlinedoctors.org – Direct-pay physicians outside the insurance model
Search for functional, naturopathic, integrative, and/or longevity physicians in your local market. Review their websites and interview them.
A high-caliber physician will order the right labs, interpret them in context, and help build a personalized plan that fits your goals.
Step 2: Make Testing a Recurring Standard
Labs aren’t a one-time event. They’re part of your R.A.D. stack—Recurring Accountability Drivers.
Whether quarterly, semi-annually or annually, testing ensures what gets measured, gets improved.
Summary:
You can’t optimize what you don’t track.
So don’t guess. Don’t wait. And don’t settle for average.
Order the labs. Run the scans. Lead your health like you lead your business—decisively.
Protect Your Brain Health
Statins have long been marketed as life-saving. But few men are warned about what they might cost—especially upstairs.
You may not hear about it in the exam room, but dig beyond page one of your search results (or more than likely five pages deep on DuckDuckGo to get to suppressed results), and you’ll find something remarkable:
A growing number of physicians and researchers are sounding the alarm that aggressively lowering cholesterol can impair cognitive function.
And the data—while politically inconvenient—is hard to ignore.
1. Your Brain Runs on Cholesterol
Cholesterol makes up 20–25% of your brain’s total content. It’s essential for:
Myelin sheath formation (protecting your neurons)
Synapse function (memory and learning)
Hormone synthesis, including testosterone and vitamin D
When you slash cholesterol—especially in the brain—you’re not just lowering a number on a lab test. You’re altering how your brain functions at the cellular level.
Dr. David Perlmutter (Grain Brain): “The brain thrives on cholesterol. The war on cholesterol is a war on cognitive health.”
2. Cognitive Side Effects Are Real—Even if They're “Rare”
Statins are known to cross the blood-brain barrier—especially lipophilic ones like simvastatin and atorvastatin.
Thousands of anecdotal reports and case studies describe:
Short-term memory loss
Brain fog, difficulty concentrating
In rare cases, transient global amnesia
Dr. Duane Graveline, a NASA astronaut and medical doctor, experienced sudden amnesia while on statins. He later published Lipitor: Thief of Memory, documenting widespread cases and pushing for further research.
Dr. Beatrice Golomb, UC San Diego researcher, has led some of the most in-depth investigations into statin side effects and found that cognitive issues are underreported and poorly understood.
3. Mainstream Medicine Dismisses It—But the FDA Didn’t Ignore It
In 2012, the FDA updated statin labels to include warnings about “memory loss and confusion.”
While large-scale studies have returned mixed results, the FDA acknowledged:
Some users experience reversible cognitive symptoms
The issue is likely underreported due to lack of recognition
Translation: It happens. But few physicians know to connect the dots.
4. Low Cholesterol May Increase Risk of Alzheimer’s
Cholesterol isn’t just neutral for brain health—it may actually be protective.
Studies have shown:
Older adults with higher LDL perform better on cognitive tests than those with low levels
(Neurology, 2014)Very low cholesterol is associated with higher risk of depression, suicide, and dementia
Dr. Georgia Ede, psychiatrist and metabolic health advocate:
“We need cholesterol for every brain cell to work. Low cholesterol is linked to increased risk of cognitive decline and psychiatric disorders.”
Dr. Dale Bredesen, author of The End of Alzheimer’s, includes optimal cholesterol management—not aggressive suppression—in his reversal protocol for neurodegenerative disease.
Bottom Line: Brain Over Bureaucracy
If you're lean, sharp, and building a bigger future, why risk trading mental clarity for a few points off your LDL?
Don’t let one-size-fits-all guidelines compromise your most valuable asset: your mind.
If you're going to stay in the game into your 70s and beyond—leading, building, mentoring—you need a brain firing on all cylinders. And that requires protecting it from dogma disguised as medicine.
The CEO’s Summary – What to Do Next
Let’s recap:
High cholesterol or high LDL is not a death sentence—especially if you’re lean, strong, and metabolically healthy.
Statins are a blunt tool, not a fix. They come with trade-offs: muscle pain, brain fog, hormonal suppression, and potential loss of libido.
The real threats are inflammation, insulin resistance, arterial plaque, and high visceral fat—not cholesterol in isolation.
Cognitive decline is not an acceptable trade-off for marginal risk reduction.
Most doctors are trained to manage disease. You’re optimizing for performance and longevity. That requires a different model.
So what do you do now?
1. Get the Right Labs
You can’t fix what you don’t measure. Order your own tests through:
Function Health
Ulta Lab Tests
Life Extension
InBody Scan
Or work with a functional medicine doctor aligned with your goals
Track:
Triglyceride-to-HDL ratio
ApoB and Lp(a)
hs-CRP
Fasting insulin
CAC score (and Cleerly if available)
Body fat%
Visceral fat
Skeletal muscle mass
2. Audit Your Context Before You Say Yes to a Statin
If you’re:
Over 20% body fat
Chronically inflamed
Sedentary
Stressed and under-recovered
...then yes—cholesterol may be contributing to risk.
But that’s not a green light for statins.
It’s a red flag to fix the real problem.
Because in this state, it’s not the cholesterol—it’s the terrain.
Inflammation, insulin resistance, and oxidative stress turn LDL into a threat.
Statins might lower the number on a lab. But they won’t fix the fire underneath.
👉 The call to action isn’t “fill the prescription.”
It’s “change the inputs.”
Train. Sleep. Clean up your diet. Manage your stress.
Drive inflammation down—and re-test.
On the other hand:
If you’ve already done the hard work—training like an athlete, sleeping like a champion, eating clean, and staying lean—your context changes everything.
Because cholesterol in a healthy system isn’t a danger.
It’s a signal to interpret, not a disease to medicate.
3. Build a Health Operating System, Not a Pill Dependency
Whether or not you ever take a statin isn’t the real question.
The real question is:
Are you building a system that runs your health—or outsourcing it to someone else’s protocol?
If you’re like most men over 50, you’ve been handed a one-size-fits-none playbook:
One number (LDL) defines your risk
One pill (statin) becomes the reflex
One doctor visit per year determines your fate
That’s not a system. That’s blind trust.
And that’s not how leaders operate.
📊 The New Standard: A Health Operating System
You run your life. You run your business.
Your health deserves the same clarity, structure, and ownership.
At Argent Alpha, we anchor everything to one powerful target: 15% body fat.
Because when you reach that level:
You’ve driven down inflammation
You’ve restored insulin sensitivity
You’ve likely reduced or eliminated visceral fat
And you’ve proven your system is working
Lean and strong men don’t face the same health risks as their overweight or obese peers.
They don’t get handed the same prescriptions.
And they sure as hell don’t wait around for decline to set in.
This is what we help you build inside Argent Alpha.
A system that tracks what matters.
A mindset that leads from the front.
And a brotherhood that won’t let you drift.
If you're ready to lead your health with clarity, data, and conviction...
We’ll show you how. Take the next step.
Coming Next Week: The Rebel Alliance
In next week’s issue, we’ll reveal the Rebel Alliance—28 world-class experts who refused to follow the script on cholesterol, statins, heart disease, and aging.
These are the cardiologists, researchers, and functional medicine pioneers—men and women—who challenged the narrative, exposed the flaws, and paid the price to tell the truth.
You’ll learn who they are, what they uncovered, and why their work could help you reclaim decades of strength, clarity, and confidence.
You’ve heard the system’s story. Now meet the people rewriting it.
The Origin of the Cholesterol Myth
If you're wondering how cholesterol became public enemy number one, it starts with one man: Ancel Keys.
In 1961, Time magazine featured Keys on its cover, praising his “discovery” that saturated fat caused heart disease. That story shaped half a century of medical policy, dietary guidelines, and pharmaceutical strategy.
But there was a problem: it wasn’t true.
Keys' famous Seven Countries Study linked saturated fat and heart disease—but he intentionally excluded countries that didn’t fit his hypothesis.
France and Germany, for example, had high fat consumption but low heart disease, and were conveniently left out.
Despite this manipulation, his work became gospel:
The U.S. government rewrote dietary guidelines
The food industry created the low-fat, high-sugar era
And doctors were taught to chase low cholesterol at all costs
Keys helped invent the “fat is bad” narrative—and we’ve been recovering from it ever since.
Today, experts like Dr. Malcolm Kendrick, Dr. Uffe Ravnskov, Dr. Robert Lustig, and Dr. Zoe Harcombe have all dismantled Keys’ conclusions. But the inertia of dogma runs deep. Many doctors still follow a playbook written by flawed science—and funded by industry.

The Time cover that changed the course of modern nutrition—without ever proving causation.
This is why you must question everything and own everything—especially when the stakes are your heart, your brain, and your future.
